Meanwhile, the overexpression of TXNIP efficiently rescued the phenotypes in ChREBP-null leukemic mice, as shown by the decreased frequencies of YFP+ peripheral blood leukemia cells, YFP+Mac-1+GR-1−undifferentiated leukemia cells, and YFP+Mac-1+c-Kit+ LICs (Figure 3F–3H) as well as the increased percentages of mature leukemia cells in the BM (Supplementary Figure 4A–4B). The gene discussed is MLXIPL; the disease is leukemia.