MLXIPL and leukemia: To further confirm the changes in the differentiation of ChREBP-null AML cells, we first examined the frequencies of YFP+Mac-1+Gr-1− leukemia cells in the BM of the mice upon primary transplantation, which was significantly increased compared to the controls (17.75 ± 2.54% vs 6.85 ± 1.72%, Figure 2A).