Further studies are needed to identify patterns of FOXP2 isoform expression in DLBCL, define its contribution to DLBCL pathogenesis and potential functional cooperativity with FOXP1, and thus elucidate the mechanisms by which FOXP2 expression contributes to poor outcome across DLBCL COO subtypes. The gene discussed is FOXP2; the disease is diffuse large B-cell lymphoma.