TGFB1 and Hepatic fibrosis: Numerous studies have shown that abnormal expression of TGF-β1 is involved in the process of virus hepatitis, hepatic fibrosis, liver cancer, hepatic failure and other chronic hepatic diseases [5–9], and TGF-β1 exerts important roles in inhibition of hepatocyte proliferation and promotion of extracellular matrix (ECM) production [10–12].