To investigate the association of VWF gene to human HSE disease, we genotyped 27 SNPs within the VWF gene and one SNP within the TNFRSF1A adjacent gene located on chromosome 12 using Taqman in 115 HSE cases and 158 EIMS (epidemiological investigation of multiple sclerosis project) controls [20]. The gene discussed is VWF; the disease is multiple sclerosis.