A previous study has shown that Dravet Syndrome, with progressive infantile onset epileptic encephalopathy caused by loss-of-function mutations in SCN1A, is correlated with natural loss of Nav1.3 channel expression in brain development, coupled with failure of increased functional Nav 1.1 channels [42]. The gene discussed is SCN3A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.