SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: A previous study has shown that Dravet Syndrome, with progressive infantile onset epileptic encephalopathy caused by loss-of-function mutations in SCN1A, is correlated with natural loss of Nav1.3 channel expression in brain development, coupled with failure of increased functional Nav 1.1 channels [42].