LDLR and atherosclerosis: Since neutrophils have been implicated in promoting the pathogenesis of atherosclerosis [25] by modulating processes associated with the vulnerability and inflammatory properties of vascular plaques [26, 27], it is reasonable to speculate that neutrophils may have influenced the plaque phenotype in Dgat1–/–→ Ldlr–/–mice or that their systemic levels reflect a response to chronically increased plaque inflammation.