Increased expression of P-cadherin (scores ≥3) was observed in 29 of 283 CIN (10.25%) and 41 of 127 SCC (32.28%) specimens compared with 2/98 NC patients (2.04%); all differences were significant (NC vs. CIN, P = 0.01; NC vs. SCC, P = 1.06E-8; CIN vs. SCC, P = 4.17E-8). This evidence concerns the gene CDH3 and cervical squamous intraepithelial neoplasia.