Levels of circulating IFN-β - IFN-I plays an essential role inantiviral defenses (Sadler & Williams 2008).To determine whether high levels of IFN-I are associated to severe dengue cases duringthe acute phase, both IFN-β and IFN-α were measured in serum/plasma from DF and DHFpatients within five days after the onset of symptoms.Fig. 2A shows that DENV patients presented similar levels of IFN-α (primaryDF: 59.05 (11.4 ~ 201.2) pg/mL; secondary DF: 50.04 (0.08 ~221.2) pg/mL; primary DHF:60.57 (1.75 ~ 165.3) pg/mL; secondary DHF: 43.30 (0 ~ 142.6) pg/mL). Here, IFNA1 is linked to dengue disease.