BRCA1 and breast cancer: Using a strategy of screening for fourcommon alterations in BRCA1 and BRCA2 (185delAG,5382insC and exon 13 6kb duplication in BRCA1 and 6174delT inBRCA2), Gomes (Gomes etal., 2007) showed a mutation frequency of 2.3% of the 5382insCmutation in 402 Brazilian breast cancer patients unselected for family history.