The ZA-dependent neutralization of M2 pro-tumoral activity brings to three main consequences: i) loss of M2 macrophages mediated enhancement of PCa cell motility; ii) reduction of stromal reactivity, due to the failure of M2 macrophages to trigger fibroblast activation; iii) inhibition of endothelial cells organization into capillary-like structures, to which cooperate both TAMs and CAFs. Here, TBX1 is linked to posterior cortical atrophy.