Indeed, the fact that sole correction of FASN upregulation, one of the most common and earliest metabolic changes in human malignancies that is not caused by mutational or gene amplification events, can reprogram metastatic cancer cells to stably recover normal-like tissue architecture, might open a new avenue to chronically restrain the life-threatening potential of metastatic carcinomas by using FASN-based differentiation therapies. This evidence concerns the gene FASN and cancer.