FASN and neoplasm: Because cellular plasticity is at the center of phenotypic reversion of the malignant phenotype, which is also linked to the concept of tumor cell stemness, it is formally possible that the activation status of FASN might dictate the degree of refractoriness of breast epithelial cells to differentiation and, therefore, their intrinsic susceptibility to the epigenetic rewiring required for the activation of a pathological differentiation program of aberrant stemness.