PIK3CA and ductal breast carcinoma in situ: A survey of the genomic alterations in the isogenic MCF10 model of BC progression, from non-malignant MCF10A cells to pre-invasive DCIS.com cells and invasive CA1 cells, has recently revealed hundreds of coding mutations in multiple cancer driver genes commonly found in primary BC (e.g., PIK3CA and TP53) [56].