Consistent with the in vitro analysis (Figure S3), expression of the mesenchymal marker vimentin was suppressed in CA1D/FASN shRNA#28 cancer tissues, while E-cadherin levels were increased (Figure 2G), suggesting that loss of FASN imposes mesenchymal-like BC tissues to undergo the inverse plastic change that generates epithelial tissue, the so-called mesenchymal-epithelial transition (MET). Here, CDH1 is linked to breast cancer.