Of the serious adverse events reported, 2 were classified by the investigators as related to GH treatment: an event of ketotic hypoglycemia in an 8.2-year-old boy with idiopathic isolated GHD treated with GH for 0.7 years, and a recurrence of craniopharyngioma in a 10.2-year-old boy who had multiple pituitary hormone deficiencies, although the diagnosis was not originally specified (hence, the patient was not included in a specific diagnostic group). This evidence concerns the gene GH1 and Hypoglycemia.