Within this regard, other parameters associated with obesity, such as abundance of macrophages, neutrophils, T cells, B cells and mast cells in adipose tissue could be further assessed in relationship to diet composition and nutritional habits, as diet-induced obesity is also associated, for example, with hyperleptinemia and resistance to leptin, as reviewed by Kanneganti and Dixit [78]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.