Lipogenic enzymes such as fatty acid synthase (FASN), acetyl-CoA carboxylase (ACC), and ATP citrate lyase (ACLY) that are involved in fatty acid biosynthesis and sterol regulatory element binding protein 1 (SREBP1), the master regulator of lipogenic gene expression, are overexpressed in a number of cancers including breast, prostate, ovarian, lung, and colon [3–6]. The gene discussed is FASN; the disease is cancer.