The significant increase in the CCR-7 transcriptional level in the MGC-803-pCMV6-RNF180-DCpG+97 cell line (following the MGC-803-pCMV6-RNF180-DCpG+102 cell line) indicated that the CpG+97 island in RNF180 DNA promoter was the other potential trigger point that promoted the chemotactic movement in the migration and invasion of gastric cancer cells. Here, RNF180 is linked to gastric cancer.