In a previous study, the methylation of ring finger protein 180 (RNF180) DNA promoter is specific to gastric cancer tissues, and four hypermethylated CpG islands, namely, CpG-116, CpG-80, CpG+97, and CpG+102, in RNF180 promoter are significantly associated with the postoperative overall survival of gastric cancer patients [14]. The gene discussed is RNF180; the disease is gastric cancer.