Notably, MGC-803-pCMV6-RNF180-DCpG+102 cancer cell lines presented the lowest MREV of Ki-67 (PCpG+102 VS vehicle =0.031), MMP-2 (PCpG+102 VS vehicle =0.034), VEGF-A (PCpG+102 VS vehicle =0.030), VEGF-D (PCpG+102 VS vehicle =0.118), and CCR-7 (PCpG+102 VS vehicle =0.001) among the above-mentioned cancer cell lines. Here, VEGFA is linked to cancer.