Additionally, MGC-803-pCMV6-RNF180-DCpG+102 cancer cell lines presented the second lowest MREV of VEGF-C (PCpG+102 VS vehicle =0.045) among the above-mentioned cancer cell lines, following by MGC-803-pCMV6-RNF180-DCpG-116 cancer cell line (PCpG+97 VS vehicle =0.036). Here, VEGFC is linked to cancer.