Moreover, disulfiram, a chelator of heavy metals and an inhibitor of aldehyde dehydrogenase, suppressed MMP2 and MMP9 activity and expression, producing an almost complete growth and invasion inhibition of osteosarcomas cells, suggesting an important role of MMP2 and MMP9 in tumor growth and metastasis [38]. The gene discussed is MMP9; the disease is osteosarcoma.