It is worth mentioning that FKBP14 knockdown induced up-regulation of Bax, caspase-3 and caspase-7 level in U-2OS and MG63 cells providing further support to the hypothesis that down-regulation of FKBP14 is more likely to elicit its apoptotic and therapeutic effects on osteosarcoma tumorigenesis. This evidence concerns the gene FKBP14 and osteosarcoma.