SULF2 and head and neck squamous cell carcinoma: SULF2 expression in HNSCC tissue was also associated with tumor grade (Figure 2B) with patients with advanced disease (stages 3 and 4) expressing a significantly higher intensity of SULF2 staining (1.38 vs 0.58, p = 0.043) and an increased proportion of stained cells (1.25 vs 0.50, p = 0.042) compared to patients with early stage HNSCC (stage 1 and 2).