The intensity of SULF2 staining was significantly increased (p-value = 0.002) in tumor cells (mean = 1.10, SD = 1.10) compared to adjacent tissue (mean = 0.40, SD = 0.76) and, consequently, the combined score was also significantly higher (p-value = 0.0005) in HNSCC (mean = 2.07, SD = 2.03) compared to adjacent tissue (mean = 0.65, SD = 1.25). The gene discussed is SULF2; the disease is neoplasm.