NFKB1 and Familial prostate cancer: Various functions have been attributed to FKBPs: FKBP52 regulates steroid hormone receptors in breast and prostate cancer cells [33–35], FKBP51 regulates Akt [36] and NF-kB pathways [37], and FKBP65 is able to directly interact with cRAF-1 [38].