To examine whether EBV LMP1-mediated DNA methylation is executed by DNMTs, we continued to detect DNMT gene expression profile in 50 NPC tissues (Figure 2B, 3A) and found that DNMT3b expression was more closely correlated with the methylation intensity at PTEN promoter than other two DNMTs (Figure 3A). The gene discussed is PTEN; the disease is nasopharyngeal carcinoma.