To date, the high CpG island methylation intensity of some tumor suppressors, RASSF1A, WIF1, DAPK1 and RARβ2, have been assessed by MS-HRM assays in NPC [43], so it is necessary to define whether DNA methylation of these promoters is also mediated by LMP1. Here, WIF1 is linked to nasopharyngeal carcinoma.