NFKB1 and nasopharyngeal carcinoma: We provided cellular and clinical evidence revealing a close correlation among LMP1 expression, DNMT3b expression, and the methylation intensity at PTEN CpG islands, and further disclosed that LMP1-mediated NF-κB up-regulated DNMT3b transcription by binding to DNMT3b promoter, leading to the higher methylation intensity at PTEN CpG islands and ultimately silencing tumor suppressor PTEN in NPC.