In this study, we focused on investigation of stearoyl-CoA desaturase-1 (SCD1) which is a critical regulator of energy metabolism and catalyzes the synthesis of monounsaturated fats, on 95 NSCLC clinical tumor samples and explored the correlation between SCD1and clinical indicators, as well as its biological effect using in vitro and in vivo lung cancer model. Here, SCD is linked to lung cancer.