It has been reported that the anti-arthritic effect of LLDT-8 is closely related to the blockade of IFN-gamma signaling (Zhou et al., 2006c ▶; Zhou et al., 2006b ▶). Therefore, LLDT-8 may be of therapeutic value in the treatment of rheumatoid arthritis. This evidence concerns the gene IFNG and rheumatoid arthritis.