Triptolide (0.0035 mg/ml for 8 weeks) blunted the increase of TLR2/TLR4 in IL-10-deficeint C57/BL6 mice via TLR/NF-κB pathway, which is related to the pathogenesis of CD (Yu et al., 2011 ▶). Here, IL10 is linked to Cowden disease.