As shown, RFC1 G80A polymorphism was not associated with increased risk of ALL under four main models (A vs. G model, OR = 1.029, 95 % CI 0.754-1.405, P=0.00; Dominant model, OR = 1.619, 95 % CI 0.847-3.094, P=0.145; recessive model, OR = 1.169, 95 % CI 10.764-1.790, P=0.429, and homozygote model, OR = 1.288, 95 % CI 0.928-1.788, P=0.130) (Figure 2a). The gene discussed is RFC1; the disease is acute lymphoblastic leukemia.