However, very recently, Kim and co-workers demonstrated that the SWI/SNF mutant cancer cells are only partially dependent on the EZH2 histone methyltransferase activity; they suggest that the dependence on EZH2 could arise from a non-enzymatic contribution of EZH2, like its role in the stabilization of the PRC2 complex [130]. The gene discussed is PRDM9; the disease is cancer.