Both inhibitors showed a good activity against the proliferation of some leukemia cell lines with MLL translocation, as MV4-11 (MLL-AF4), MOLM-13 (MLL-AF9), and THP1 (MLL-AF9), with little effect on leukemia cells lacking this translocation [71, 72, 77]. The gene discussed is AFF1; the disease is leukemia.