In November 2015, Epizyme began a phase 1 study of tazemetostat in pediatric subjects with relapsed or refractory integrase interactor 1 (INI1) negative tumors or synovial sarcoma (ClinicalTrials.gov identifier: NCT 02601937) and a phase II study for adult patients with a similar cancer (ClinicalTrials.gov identifier: NCT 02601950). Here, SMARCB1 is linked to cancer.