Heterozygous Tyr 641 mutations in the catalytic EZH2 SET domain, for example, were also identified in some myeloid malignancies, especially in follicular lymphoma (7.2 %) and in diffuse large B cell lymphoma (DLBCL) (21.7 %) that derive from germinal center B cells [110]. Here, EZH2 is linked to diffuse large B-cell lymphoma.