VEGFA and von Hippel-Lindau disease: HIF downstream target genes [44] include vascular endothelial growth factor A (VEGFA) [45, 46], solute carrier family 2 member 1 (SLC2A1, which was also called GLUT1), and platelet-derived growth factor-β (PDGFB) [47], which were known to drive cell growth and proliferation of microvascular vessels in VHL syndrome [42].