DOCK8 deficiency accounts for the majority of AR-HIES [61–64] and is characterized by extensive cutaneous viral infections (herpes simplex, varicella zoster, human papillomavirus, and molluscum contagiosum), central nervous system (CNS) complications, elevated IgE, and eosinophilia [61, 65, 66]. Here, IGHE is linked to Autosomal recessive hyper-IgE syndrome.