IGHE and asthma: In this connection, in a mouse model of chemical-induced asthma previously developed by our group using AP [9], we showed that AP, after two dermal applications and only one airway challenge, can induce features of human occupational asthma in mice, including respiratory responsiveness to methacholine, neutrophil inflammation in BAL, T- and B cell proliferation and a Th2 cytokine profile in the auricular lymph nodes (the site of sensitization), and also increased total serum IgE levels.