When carriers of the 1‐2 risk allele and with lower HO‐1 activity (≤32.1 pg/ml) were used as a reference, individuals with the 0 risk allele and higher HO‐1 activity (>32.1 pg/ml) had a decreased risk of vitiligo (adjusted OR = 0.43, 95% CI = 0.23–0.79). Here, HMOX1 is linked to vitiligo.