Various elements of the innate immune response have been implicated in the cellular reaction to, and restriction of, flavivirus infection, including type I and type III interferon (IFN), IFN-stimulated tripartite motif (TRIM) proteins, mitochondrial activated antiviral signaling (MAVS), and interleukins (26, 27). Here, IFNA1 is linked to Flavivirus Infections.