He et al. demonstrated that miR‐224 was up‐regulated in esophageal intraepithelial neoplasia and esophageal squamous cell carcinoma and that miR‐224 overexpression increased esophageal squamous cell carcinoma cell migration, proliferation and invasion by inhibiting PHLPP1 and PHLPP2 35. This evidence concerns the gene PHLPP2 and esophageal squamous cell carcinoma.