SACK1H and ameloblastoma: In the present study, we showed that FAM83H and its associated protein, CK-1ε, are localized on keratin filaments in mouse dental enamel cells such as ameloblasts and stratum intermedium cells in vivo, and suggested that FAM83H regulates the organization of the keratin cytoskeleton and its truncated mutants disorganize the keratin cytoskeleton in a manner dependent on its CK-1 binding in human ameloblastoma cell lines.