Based on our asymptomatic screening cohort, the combination of serum NDKA and FIT allowed the identification of the 4 CRC cases besides 41.51% (22/53) and 45.28% (24/53) of the AA (94.79 ng/mL or 82.21 pg/mL NDKA cut-off, respectively), with a considerable increase in the detection of proximal adenomas compared with only FIT. This evidence concerns the gene NME1 and adenoma.