These data show that leukocytes from HDs, whether PBMCs or peripheral blood B lymphocytes, are characterized by low P2X7R and ASC expression and high NLRP3 levels, while CLL lymphocytes on the contrary are characterized by high P2X7R and ASC expression and low NLRP3 levels. The gene discussed is NLRP3; the disease is B-cell chronic lymphocytic leukemia.