The activation of the EMT program is a hallmark feature of the mesenchymal CMS4 of CRC and the TGFβ signaling pathway—a known inducer of this process (Moustakas & Heldin, 2007)—is predicted to be active in CMS4 tumors (Guinney et al, 2015). Here, TGFB1 is linked to colorectal carcinoma.