TGFB1 and colorectal carcinoma: Taken together, these data point to the fact that TGFβ is indeed a critical cue to direct SSA precursor lesions to the mesenchymal, poor‐prognosis CMS4 of CRC and offer a possible explanation as to how the same pre‐neoplastic lesion might spawn CRCs belonging to the most favorable and the most dismal prognosis subtype.