TGFB1 and colorectal carcinoma: Taken together, these data indicate that (i) the TGFβ pathway is operational in premalignant SSAs, that (ii) SSAs are characterized by higher activity of TGFβ signaling compared to TAs, and that (iii) in CMS4‐SSAs TGFβ activity is elevated even further, suggesting that high levels of TGFβ signaling direct SSAs to the CMS4 of CRC (Fig 4D).