Since the EMT phenotype—a hallmark of the mesenchymal colon cancer subtype—can be induced by TGFβ, and the TGFβ signaling pathway is predicted to be active based on gene expression in CMS4 CRCs (Guinney et al, 2015) and SSAs (De Sousa E Melo et al, 2013), we wondered whether TGFβ might also dictate subtype‐specific gene expression. The gene discussed is TGFB1; the disease is malignant colon neoplasm.