Hyperglycemia (associated with diabetes mellitus—DM) can lead to enhanced oxidative stress, phosphorylation of p53, and mitochondrial dysfunction and damage, resulting in apoptosis (Polyak et al, 1997; von Harsdorf et al, 1999; Li et al, 1999; Tang et al, 2014). This evidence concerns the gene TP53 and Hyperglycemia.