A DUF1669-independent association between FAM83H, keratin 18, and casein kinase −1α (CK-1α) results in CK-1-mediated disassembly of keratin filaments and a loss of epithelial cell polarity, which may have significant implications in colon cancer invasion and metastasis [89]. Here, CSNK1A1 is linked to malignant colon neoplasm.