CD8A and neoplasm: Significant differences in the localization pattern of immune cell density between the four tumor regions were confirmed for CD3+ (p = 0.002), CD4+ (p = 0.015), CD8+ (p = 0.006), CD20+ (p = 0.007), CD25+ (p = 0.008) and CD68+ (p = 0.010) cells by Friedman two-way ANOVAs.