LUZP2 and pachyonychia congenita: Therefore, our data consistently showed that expression of LUZP2 mRNA was much higher in hormone-naïve PC cells in culture, PDX models in mice and patient tissues in comparison to the CRPC counterparts, suggesting that downregulation of LUZP2 might be a contributing factor in the development process from PC to CRPC, but its upregulation may be important for development of enzalutamide resistance.