CREB3 and Intellectual disability: LUZP2 (leucine zipper protein 2 gene) encodes a leucine zipper protein that has been reported to be deleted in some patients with Wilms tumor-Aniridia-Genitourinary anomalies-mental Retardation (WAGR) syndrome, which is a rare congenital anomaly syndrome consisting of Wilm's tumor, aniridia, genitalanomalies and mental retardation [46, 47].