Significantly, tumor tissues derived from UMUC-3/shScr xenografts showed reduced expression of the epithelial marker E-cadherin (Figure 7D) and enhanced levels of the mesenchimal protein vimentin (Figure 7E) compared to UMUC-3/shPGRN orthotopic xenografts suggesting that progranulin-associated tumorigenesis of UMUC-3 cells might be, at least in part, associated with an epithelial-to-mesenchimal (EMT) transition [22], which is severely affected by progranulin depletion. This evidence concerns the gene CDH1 and neoplasm.