Importantly, 70% of UMUC-3/shScr cells generated tumor xenografts (Figure 6A, 6B) in contrast to progranulin-depleted UMUC-3 cells of which only 12% generated xenografts with an average tumor volume significantly smaller than control (***P < 0.001, Figure 6A, 6B). The gene discussed is GRN; the disease is neoplasm.