Notably, in UMUC-3/shPGRN derived tissue we could notice an intact and well assembled F-actin network, which was severely disrupted in control tissue derived from UMUC-3/shScr xenografts (Figure 7B, arrows in Insets), confirming our previous results indicating that progranulin regulates invasion, motility and proliferation of cancer cells by modulating F-actin remodeling [18]. Here, GRN is linked to cancer.