GRN and carcinoma: In order to include in this analysis low grade superficial urothelial carcinomas, we tested progranulin expression levels in archived paraffin-embedded tissues derived from 4 non-invasive carcinoma in-situ (Tis), 4 non-invasive low grade papillary carcinomas (Ta), 4 non-invasive high grade papillary carcinomas (Ta) using as control normal and invasive high grade carcinoma tissues (n = 4).