GRN and papillary carcinoma: Progranulin expression levels were considerably up-regulated in non-invasive low grade papillary carcinomas (Ta) (***P < 0.001 compared to benign tissues, Figure 9C, 9D) and enhanced in both non-invasive high grade papillary carcinomas (Ta) and high grade carcinoma tissues (*P < 0.01 compared to benign tissues, Figure 9C, 9D).