Multiple studies have characterized genome-wide mutational spectra of HCC [7–13], and identified at least 25 candidate driver genes with recurrent genetic alterations [14], including TP53, CTNNB1, and ARID1A. RNA-seq has identified new isoforms, fusion genes, and functional pathways that are altered in HCC [15–19]. Here, CTNNB1 is linked to hepatocellular carcinoma.