The effect of PB against BRCA1 mutated ovarian cancers were previously reported from our laboratory with evidences directing to the modulation of Estrogen Receptor (ER) α, a 46 kDa isoform, playing a critical role in blocking the classical ER signaling in ER over expressing ovarian cancer cells7, 8, 9. The gene discussed is BRCA1; the disease is ovarian cancer.