Our group has earlier shown that antisense blocking of BRCA1 in BG1 ovarian cancer cells resulted in the induction of apoptosis in response to treatment with PB (2-hydroxy-5-methyl-1,4-naphthaquinone), a naphthaquinone isolated from plumbago plant species7, 8, 9. The gene discussed is BRCA1; the disease is ovarian cancer.