Moreover, while none of the subjects analyzed in this study had a DBS-determined LAL activity compatible with the diagnosis of Wolman or CESD, i.e. <0.03 nmol/spot/h [8], 14% of cryptogenic cirrhotics and 20% of cirrhotics of known etiology, but only 1 (1%) of controls, showed a LAL activity in the range which has been described in heterozygous carriers of LIPA gene mutations, i.e., in the range 0.15–0.40 nmol/spot/h [8] (Fig 1, Panel B). The gene discussed is LIPA; the disease is cholesteryl ester storage disease.