Genes upregulated in archival comparison of MDD versus controls also showed significant over-representation of CREB and NRF2 TFBMs, and genes upregulated in cancer patients with high levels of depressive symptoms showed significant over-representation of CREB/ATF TFBMs and marginally significant (P=0.059) over-representation of NRF2 TFBMs. The gene discussed is NFE2L2; the disease is major depressive disorder.