Prominent among upregulated transcripts were gene products involved in Type I interferon response, including several that were upregulated in the MDD versus control baseline comparison (marked with *); these were IFI27, IFI44*, IFI44L*, IFI6*, IFIT1, IRF7, ISG15, OAS1, OAS2, OAS3* and OASL*. This evidence concerns the gene OAS3 and major depressive disorder.