Ancillary analyses adjusting gene expression data for age, sex, body mass index and the fractional distribution of lymphocytes, monocytes and eosinophils in the assayed leukocyte pool (Table 2) continued to indicate over-representation of CREB/ATF and NRF2 response elements in promoters of genes upregulated in association with MDD. This evidence concerns the gene NFE2L2 and major depressive disorder.