Genes upregulated in archival comparison of MDD versus controls also showed significant over-representation of CREB and NRF2 TFBMs, and genes upregulated in cancer patients with high levels of depressive symptoms showed significant over-representation of CREB/ATF TFBMs and marginally significant (P=0.059) over-representation of NRF2 TFBMs. This evidence concerns the gene CREB1 and major depressive disorder.