Studies have also implicated the association of the NLGN1 gene with other psychiatric disorders like autism spectrum disorders and schizophrenia.82, 83 Reduced excitatory synaptic transmission could be a promising mechanism and treatment target for behavioral abnormalities.51 Approaches to enhancing NMDA function may be particularly effective in those with low NLGN1 expression in the brain. Here, NLGN1 is linked to schizophrenia.