NLGN1 and psychiatric disorder: Studies have also implicated the association of the NLGN1 gene with other psychiatric disorders like autism spectrum disorders and schizophrenia.82, 83 Reduced excitatory synaptic transmission could be a promising mechanism and treatment target for behavioral abnormalities.51 Approaches to enhancing NMDA function may be particularly effective in those with low NLGN1 expression in the brain.