NLGN1 and post-traumatic stress disorder: Interestingly, NLGN1 knockout mice exhibit behavioral changes linked to cerebellar and orbitofrontal cortex abnormalities.51, 52 Together these data suggest that variants within a gene associated with learning and memory function across cerebellar and cortical areas in mice are also associated with decreased expression and putatively decreased synaptic function, in similar areas in subjects with PTSD.