Short-term treatments (9 h) with DXR alone at 1 and 10 μM significantly increased AKT phosphorylation by 2.5 ± 0.11-fold and 5.0 ± 0.68-fold in synovial sarcoma cells (Fig 6B) and by 1.57 ± 0.26-fold and 2.0 ± 0.11-fold in leiomyosarcoma cells (Fig 6B). This evidence concerns the gene AKT1 and leiomyosarcoma.