Interestingly, immunohistochemical studies found elevated phosphorylation of AKT and a concomitant up-regulation of downstream effectors (e.g., GSK3β and β-catenin) in tumors of patients with STS, especially in synovial sarcoma [23, 24] and leiomyosarcoma [25]. This evidence concerns the gene AKT1 and telomere syndrome.