Likewise, UA (5–30 μM) strongly decreased total p21 levels, reaching a maximal decrease of 73.4 ± 7.9% in synovial sarcoma and 57.8 ± 3.9% in leiomyosarcoma cells after 9 or 12 h of treatment, respectively (Fig 5). This evidence concerns the gene CDKN1A and leiomyosarcoma.