Although some former studies have linked AKT inhibition to UA-induced suppression of growth and intrinsic apoptosis in certain human carcinoma [10, 36, 37] and leukemia cells [38], our study presents the first evidence that UA is able to suppress proliferation and to induce intrinsic apoptosis through AKT inhibition in human STS cell lines. This evidence concerns the gene AKT1 and telomere syndrome.