Short-term treatment with UA (6 and 9 h) drastically decreased phosphorylation of AKT in a dose-dependent manner, reaching a maximal inhibition of 94.4 ± 2.7% in synovial sarcoma (Fig 4) and of 67.6 ± 0.5% in leiomyosarcoma cells (data not shown) at 30 μM in both cases, while total AKT levels remained unchanged. This evidence concerns the gene AKT1 and leiomyosarcoma.