However, we recently demonstrated that PEA directly reduces the release of pro-angiogenic factors in an in vitro model of colon cancer cells, through an Akt-mTOR pathway-dependent VEGF inhibition; these results suggest that the anti-angiogenic activity displayed by PEA in the inflamed colon is not solely related by its anti-inflammatory effects [23]. This evidence concerns the gene AKT1 and colonic neoplasm.