ANO1 which is a type of CaCC that can be found in various types of cells including enterocyte, DRG neuron, airway epithelial cells and vascular smooth muscle cells is overexpressed in several types of human carcinomas including head-and-neck squamous cell carcinoma (HNSCC), GIST, breast and prostate cancer [6, 13, 14, 17, 18, 30–33]. Here, ANO1 is linked to head and neck squamous cell carcinoma.