Also, we could see that kidney function as estimated by eGFR-CG was highly significantly associated with incident MetS, and further that cystatin C′s association with incident MetS remained significant when eGFR was taking into account in the multivariate logistic regression analysis, data that further stresses the notion that cystatin C is a reflector of increased risk of MetS due to renal dysfunction. The gene discussed is CST3; the disease is Abnormal renal physiology.