In the logistic regression regarding risk of developing incident MetS in the whole MDC-re-examination cohort when adding eGFR-CG on top of model 2 showed that each 1 SD change of eGFR-CG was highly significantly associated with incident MetS (OR 1.41 95% CI (1.21–1.64), p = 1.00x10-5, and the relation of cystatin C with incident MetS was (OR 1.14 (1.02–1.27), p = 0.019). Here, CST3 is linked to metabolic syndrome.