In the replication cohort of MDC-CC-re-exam, the OR (95% CI) for incident MetS in subjects belonging to quartiles 1, 2, 3 and 4 of plasma cystatin C levels was 1.00 (reference), 1.21 (0.70–2.07), 1.62 (0.95–2.78) and 1.72 (1.01–2.93) (ptrend = 0.026) in age and sex adjusted analysis. This evidence concerns the gene CST3 and metabolic syndrome.