It was reported by Pauline et al. that an unbalanced maternally inherited complex chromosome rearrangement in a boy with coronal craniosynostosis and intellectual disability was due to 3.64Mb heterozygous deletion of 15q21.3q22.2 region, this deletion leads to haploinsufficiency of TCF12 gene [30]. Here, TCF12 is linked to craniosynostosis.