TP53 and colorectal carcinoma: Our data suggested that NMNAT2 is likely to be a key linker between NAD and p53, and its expression is correlated with p53 in CRC, which is consistent with previous speculations that NMNAT2 is a downstream target of p53 and NMNAT2 could be induced in a p53-independent manner in human CRC cell line HCT116 [30].