The first GWAS and subsequent follow-up performed on Han Chinese populations identified the following PCOS candidate loci: DENND1A, INSR, YAP1, C9orf3, RAB5B, HMGA2, TOX3, SUMO1P1/ZNF217, THADA, follicle-stimulating hormone receptor (FSHR), luteinizing hormone/choriogonadotropin receptor (LHCGR) (6,7). The gene discussed is RAB5B; the disease is polycystic ovary syndrome.